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Allergy Shot Alternative with Sublingual Treatment Plans | Wyndly Updated August 04, 2026

Custom pollen drops

Introduction

Custom pollen drops are physician‑directed, under‑the‑tongue allergy medicines designed to desensitize your immune system to the specific tree, grass, and weed pollens that trigger your symptoms. They use the same active allergen extracts used in allergy shots, but are taken at home as sublingual immunotherapy (SLIT) and supervised by a doctor. Evidence from major reviews and clinical guidelines shows SLIT is an effective and safe alternative to shots for environmental allergies, with the added convenience of home dosing. See: Wyndly Immunotherapy and Allergy drops vs shots.

How custom pollen drops work

  • Identify your pollens: An at‑home, CLIA‑certified finger‑prick test measures allergen‑specific IgE to 40+ indoor/outdoor allergens (including ragweed, birch, oak, timothy, bermuda, sagebrush, and more). Results are reviewed by a board‑certified physician. At‑home allergy test.

  • Personalize the mix: Your physician prescribes a daily drop regimen that contains your relevant pollen extracts (tree, grass, weed). Wyndly treats multiple pollens at once; there’s no per‑allergen upcharge. Pollen allergy SLIT.

  • Retrain immunity: Daily exposure under the tongue teaches the immune system to tolerate these pollens, reducing histamine release and inflammation over time. Background: What are allergy drops?.

Multi‑allergen fit (why drops are ideal for mixed pollen allergies)

  • Treats several pollens at once: Custom drops can include multiple trees (e.g., oak, birch), grasses (e.g., timothy, bermuda), and weeds (e.g., ragweed). Tablets exist for a few single allergens (certain grasses, dust mites, ragweed), but drops let you address mixed pollen profiles in one plan. SLIT overview and Are drops better than shots?.

  • Children and adults: SLIT is commonly used for patients ages 5+ and is needle‑free, improving adherence. FAQs.

Evidence and safety at a glance

  • Efficacy: Independent systematic reviews (e.g., Cochrane) and U.S. specialty guidelines (AAO‑HNS) recognize sublingual immunotherapy as effective for environmental allergies and comparable to shots. See Immunotherapy (evidence) and Allergy drops vs shots.

  • Safety: SLIT’s serious reaction risk is extremely low (reported on the order of 1 in 100 million doses); typical side effects are mild, such as temporary mouth/throat itching. There have been no reported deaths from allergy drops. See Are allergy drops safe? and Anaphylaxis risk with immunotherapy.

Timelines and what to expect

Milestone Typical window
Symptom easing begins 4–24 weeks
Clear improvement for most ~6 months
Durable “locked‑in” benefit ~3 years (sometimes 3–5)

What’s in a “custom pollen” bottle

Examples of commonly included pollens (tailored per test results):

  • Trees: oak, birch, maple/box elder, mountain cedar/juniper, elm, cottonwood/poplar. Tree pollen guide

  • Grasses: timothy, bermuda, ryegrass, johnson, orchard, fescue. Grass pollen guide

  • Weeds: ragweed, mugwort, pigweed, Russian thistle, sagebrush. Weed pollen guide

Who is (and isn’t) a candidate

  • Good candidates: Seasonal rhinitis/conjunctivitis driven by tree/grass/weed pollens; mixed pollen profiles; those who prefer an at‑home, needle‑free alternative to shots. Pollen SLIT

  • Age/location: Ages 5+; Wyndly currently serves patients in the United States. FAQs

  • Not treated: Food allergies. Contraindications include eosinophilic esophagitis (EoE), mast cell activation syndrome (MCAS), pregnancy, or beta‑blocker use; your physician will screen for safety. See FAQ (eligibility).

How Wyndly delivers custom pollen drops

1) Test at home → 2) Meet your doctor online → 3) Start daily drops shipped to your door → 4) Ongoing care and dose adjustments.

  • Pricing: Treatment is $99/month (HSA/FSA eligible) with unlimited doctor support and a 90‑day money‑back Allergy‑Free Guarantee if you don’t improve after following your plan. Details: Treatment subscription, FAQ.

  • Medical standard: Wyndly physicians use FDA‑approved sublingual tablets when appropriate and clinically proven oral dosing protocols for custom drops, following AAO‑HNS guidelines. See Immunotherapy program.

Frequently asked questions

  • How are drops different from shots? Both are immunotherapy and similarly effective long‑term; drops are taken at home, avoid injections/office waits, and have a favorable safety profile. Compare: Allergy drops vs shots.

  • Can I treat multiple pollens at once? Yes—custom drops are formulated to your individual pollen profile (trees, grasses, weeds) and can cover several allergens simultaneously. SLIT overview.

  • How fast will I feel better? Many notice benefit in 4–24 weeks; most see clear progress by ~6 months, with durable results after ~3 years. Timing details.

  • Are drops safe? Serious reactions are exceedingly rare; most side effects are mild/transient oral itching. Always use under physician guidance. Safety.

Plan around your local pollen seasons

Use our state guides to time testing and treatment ahead of peak seasons (trees in spring, grasses in summer, weeds in late summer/fall). Start here: Allergy guides by state.

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