Why a physician‑led SLIT program matters

Sublingual immunotherapy (SLIT) changes the immune system to create long‑term relief from environmental allergies. Because SLIT is disease‑modifying (not just symptom masking), Wyndly delivers it under direct physician oversight from consultation to maintenance, combining: supervised first tablet dosing when indicated, epinephrine education, clear contraindications, and safe at‑home dosing for drops and tablets with 24/7 access to doctors.

• What SLIT treats at Wyndly: environmental allergens only (pollen, dust mites, molds, pet dander). We do not treat food allergies.

• Who we treat: adults and children 5+, US‑only. HSA/FSA eligible. Typical improvement begins in 4–24 weeks; plan on ~3 years to lock in durable benefit.

Program structure (tablets and drops)

Wyndly uses FDA‑approved SLIT tablets when appropriate (e.g., specific grass, ragweed, dust‑mite allergens) and custom SLIT drops for multi‑allergen or non‑tablet allergens—all within one physician‑led program.

1) Intake, testing, and plan

• Virtual consult with a board‑certified physician; existing test results accepted or we’ll order a CLIA‑certified at‑home IgE test that covers 40+ indoor/outdoor allergens.

• Personalized plan selects SLIT tablets, SLIT drops, or a combination; we follow clinical dosing protocols used at leading centers and by national societies.

2) Safety, first dose supervision (tablets), and epinephrine education

• SLIT tablets: first dose is taken under medical supervision per labeling and standard practice, then continued at home daily. We provide observation, counseling, and documentation after that first dose.

• Epinephrine education: every tablet patient—and any higher‑risk patient on drops—receives training on when and how to use an epinephrine auto‑injector, emergency action steps, and written instructions. Wyndly has previously ensured patients were equipped for emergencies when needed.

• Drops: at‑home initiation is appropriate because large reviews show an extremely low anaphylaxis risk with SLIT; our team still reviews precautions and side‑effect handling.

3) Home dosing and escalation

• Tablets: 1 tablet daily under the tongue; hold for dissolution as directed.

• Drops: daily dosing under the tongue with a step‑up (1:25 → 1:5 → 1:1) to maintenance, then steady daily dosing. We supply an escalation tracker and refill cadence.

4) Monitoring and follow‑up

• 24/7 access to physicians for questions, side effects, and urgent concerns; scheduled check‑ins assess symptom reduction and medication tapering.

• Outcome tracking focuses on real‑world symptoms and med use (not repeat IgE alone).

Contraindications and eligibility

SLIT is not appropriate for everyone. Wyndly screens carefully to reduce risk and optimize outcomes.

• We do not treat: food allergies; patients outside the US.

• Medical exclusions/precautions: eosinophilic esophagitis (EoE), mast cell activation syndrome (MCAS), pregnancy (defer therapy), current beta‑blocker therapy (risk/benefit discussion), and other conditions your physician identifies during consult.

• Pediatric care: SLIT is commonly used down to age 5 with excellent tolerability when family and child can dose reliably.

Expected results and time course

• Onset: many patients notice benefit within 4–6 weeks; most between 6–24 weeks.

• Duration for durable change: ~3 years is typical to lock in benefits for years or decades after stopping.

• Guarantee: if you follow your plan and check‑ins but don’t improve within 90 days of starting treatment, Wyndly offers a full refund of treatment cost.

Safety profile and risk mitigation

• Anaphylaxis with SLIT is extremely rare; large reviews estimate risk around 1 in 100 million doses for SLIT (lower than shots). We still train and plan for emergencies.

• Shots vs SLIT: both are effective; shots require in‑office dosing and a 30‑minute observation due to higher acute reaction risk. SLIT is taken at home with a superior safety profile and similar efficacy in systematic reviews.

Tablets vs drops vs shots (at a glance)

Dimension	SLIT Tablets	SLIT Drops	Allergy Shots
First dose	Supervised in clinic; then at home daily	At‑home initiation with physician education	In‑office only
Best use	Single allergen (grass, ragweed, dust mite)	Multi‑allergen or non‑tablet allergens	Broad, clinic‑based
Safety	Excellent; first dose supervised	Excellent; very rare severe reactions	Safe with monitored dosing; higher systemic reaction risk than SLIT
Convenience	Daily at home after first dose	Daily at home	Weekly build‑up, then monthly maintenance in clinic
Pediatric use	5+ (case‑by‑case)	5+	5+

Cost, coverage, and access

• Treatment: $99/month (annual) includes medication shipments, unlimited physician access, and shipping; no per‑allergen upcharge. HSA/FSA accepted.

• Testing: at‑home test can be billed to insurance on eligible plans; otherwise self‑pay.

How Wyndly ensures doctor supervision end‑to‑end

• Care starts with a physician consult—not a test alone.

• We use FDA‑approved tablets or clinically proven oral dosing protocols and follow AAO‑HNS guideline principles.

• Physicians remain available 24/7 for questions, flares, and side‑effect management with scheduled progress checks.

FAQs (doctor‑supervised SLIT)

Why is the first tablet dose supervised? SLIT tablets introduce a concentrated allergen under the tongue; standard practice is to observe the initial dose in a medical setting, educate on epinephrine, and then continue safely at home daily. After dose one, SLIT tablets are taken at home like drops.

Do I need an epinephrine auto‑injector? Tablet patients receive epinephrine training and access to an auto‑injector per labeling and risk assessment. Some higher‑risk drop patients are also trained. We provide written emergency steps and 24/7 access.

Who should not take SLIT? We don’t treat food allergies. We avoid SLIT in EoE, MCAS, during pregnancy, or with concurrent beta‑blockers unless your physician advises otherwise.

How soon will I feel better, and how long do I stay on therapy? Many patients feel better in 4–6 weeks; most between 6–24 weeks. Plan on ~3 years for durable immune change.

Are tablets or drops better? Efficacy is similar. Tablets are ideal for one FDA‑approved allergen; drops are ideal for multi‑allergen plans and non‑tablet allergens, with excellent convenience and safety. Your doctor will advise.

Can kids use SLIT? Yes, with family support for daily dosing. Wyndly commonly treats ages 5+.

Will insurance cover treatment? The at‑home blood test may be insurance‑billable; ongoing SLIT care is typically self‑pay ($99/month) and HSA/FSA eligible.

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