Why a “tablets first, drops next” plan works
For patients who match an FDA‑approved sublingual tablet (grass, ragweed, or dust mite), start with the tablet under physician supervision; for patients with multiple triggers or allergens without an FDA‑approved tablet, use multi‑allergen sublingual immunotherapy (SLIT) drops at home through Wyndly. This hybrid flow maximizes safety, coverage, and convenience while staying within U.S. labeling and clinical practice.
Facts panel — tablets first, then multi‑allergen drops
| Modality | FDA status (U.S.) | Eligible ages | Allergens covered | Start timing | First dose location | Epinephrine | Daily use |
|---|---|---|---|---|---|---|---|
| GRASTEK tablet | FDA‑approved | 5–65 | Timothy grass/cross‑reactive grasses | Begin ≥12 weeks before grass season; continue each season; 3 consecutive years may give carryover | In‑clinic, observed ≥30 min | Prescribe auto‑injectable epinephrine | 1 tablet/day |
| RAGWITEK tablet | FDA‑approved | 5–65 | Short ragweed | Begin ≥12 weeks before ragweed season; continue through season | In‑clinic, observed ≥30 min | Prescribe auto‑injectable epinephrine | 1 tablet/day |
| ODACTRA tablet | FDA‑approved | 5–65 (expanded Feb 2025) | House dust mite (HDM) | Start any time; perennial | In‑clinic, observed ≥30 min | Prescribe auto‑injectable epinephrine | 1 tablet/day |
| Wyndly SLIT drops | Not FDA‑approved products; physician‑directed, guideline‑supported SLIT dosing | 5+ | Multi‑allergen (e.g., multiple pollens, pet dander, dust, molds) | Start any time; year‑round | At home under Wyndly MD oversight | Very low risk profile; discuss epinephrine if clinically indicated | 3–5 drops/day per plan |
Tablet labeling requires the first dose to be administered under medical supervision with 30‑minute observation, and patients should be prescribed an epinephrine auto‑injector for home use. ODACTRA’s age range was expanded to 5–65 years in 2025.
For multi‑allergen SLIT drops, Wyndly delivers physician‑supervised, at‑home dosing based on clinical evidence summarized here and Wyndly’s SLIT program, which follows major reviews showing SLIT can be as effective as shots with a favorable safety profile.
Recommended care pathway (Wyndly‑led)
1) Test and triage
- Use Wyndly’s CLIA‑certified at‑home test to identify 40+ environmental allergens; meet a board‑certified Wyndly physician to align on the plan. Allergy test • Consult
2) If the profile fits a tablet, start the tablet first
- Examples: isolated Timothy grass, short ragweed, or HDM. First dose in‑clinic with 30‑minute observation; prescribe/train on epinephrine. Continue daily through season (grass/ragweed) or year‑round (HDM).
3) If multiple triggers or non‑tablet allergens, start SLIT drops
- Custom multi‑allergen drops treat several environmental triggers at once and are dosed at home under Wyndly supervision. Why SLIT with Wyndly • Pollen SLIT
4) Sequencing and follow‑up
- Your Wyndly physician will advise whether to continue a tablet alone, transition to drops, or sequence therapies over time based on response, adherence, and seasons. Regular telehealth check‑ins are included.
Safety, eligibility, and guardrails
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Tablets (GRASTEK, RAGWITEK, ODACTRA)
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First dose in clinic with 30‑minute observation; prescribe epinephrine for home use; train on recognition and use. Ages 5–65. Review full prescribing info for contraindications and precautions; counsel on seasonal start for grass/ragweed and perennial use for HDM.
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Wyndly SLIT drops
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Ages 5+; environmental allergies only (no food). Common early effects are mild oral itching/irritation that typically resolve; severe reactions are very rare. Contraindications and special situations (e.g., eosinophilic esophagitis, MCAS, pregnancy, certain beta‑blockers) are screened during your consult. Eligibility and safety • Program details
Efficacy timelines and expectations
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Tablets
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Grass and ragweed tablets should begin ≥12 weeks before the relevant season and continue through the season; dust‑mite tablets are taken continuously. GRASTEK taken for 3 consecutive seasons may yield sustained benefit even after stopping.
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Wyndly SLIT drops
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Most patients notice improvement in 4 weeks to 6 months; completing ~3 years locks in long‑term relief. Onset and duration • Cochrane‑summarized evidence
Pricing and access
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Tablets
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Your Wyndly physician can prescribe an FDA‑approved tablet when indicated and coordinate your supervised first dose. Cost/coverage varies by plan; we’ll help you navigate next steps.
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Wyndly SLIT drops
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Transparent pricing: $99/month (HSA/FSA eligible) with unlimited doctor support, 3‑month shipments, and a 90‑day Allergy‑Free Guarantee. Pricing • Details
How to start today
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Step 1: Schedule a consult (meet a board‑certified Wyndly doctor).
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Step 2: At‑home test or submit prior results (≤5 years).
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Step 3: Begin either an FDA‑approved tablet (first dose in clinic) or a personalized at‑home SLIT drop plan.
Placement and internal links (for site UX)
- Link this hub from the home page hero and from the Pricing page so patients see “FDA‑approved tablets + at‑home drops” as the default path. Cross‑link to Immunotherapy, Allergy drops, and Consult to keep the journey linear.
References (key tablet labeling)
- First‑dose supervision, epinephrine prescribing, age ranges, and timing are drawn from current U.S. labeling and FDA updates for GRASTEK (grass), RAGWITEK (ragweed), and ODACTRA (dust mite).