Do FDA-approved SLIT tablets require a supervised first dose?

Yes. Grass (Grastek, Oralair), ragweed (Ragwitek), and dust mite (Odactra) tablets require the first dose under medical supervision with at least 30 minutes of observation.

What ages are tablets approved for in the U.S.?

Current U.S. labels generally indicate use for ages 5–65. Your clinician will confirm product-specific eligibility and timing.

Do I need an epinephrine auto-injector at home?

Yes. Patients must be prescribed an epinephrine auto-injector and receive training before any home dosing. Keep it accessible while on therapy.

Are tablets approved for ages 5–65?

Yes. Current U.S. labels for Grastek, Oralair, Ragwitek, and Odactra indicate use for ages 5–65. The first dose must be observed with at least 30 minutes of monitoring, and patients must receive epinephrine training before home dosing.

What ages are SLIT tablets approved for in the U.S., and do I need to keep epinephrine at home?

Current U.S. labels approve SLIT tablets for ages 5–65 (product-specific). Patients should have an epinephrine auto-injector available at home and be trained to use it while on therapy.

How does Wyndly coordinate my supervised first tablet dose if I'm not near your clinic?

Wyndly arranges in-person first-dose observation with approved partner clinics in all 50 states. We schedule your visit, ensure ≥30 minutes of monitoring, and provide an epinephrine prescription and training before you begin home dosing.

Do SLIT tablets and drops have different first-dose rules?

Yes. FDA-approved tablets (Grastek, Oralair, Ragwitek, Odactra) require an in-clinic first dose with at least 30 minutes of observation. Custom SLIT drops are taken at home and do not require a supervised first dose.

Do I need an epinephrine auto-injector?

For SLIT tablets, an epinephrine auto-injector must be prescribed and training provided before home dosing. For SLIT drops, routine prescribing is not required for all patients; your clinician may prescribe based on your history and risk.

How long will I be observed after the first dose?

Plan to remain in the clinic for at least 30 minutes after your first supervised tablet dose so staff and emergency medicines are immediately available.

Do I need an epinephrine auto-injector for SLIT tablets?

Yes. An epinephrine auto-injector must be prescribed and you (or your caregiver) will be trained to use it during your first-dose visit. Keep it accessible while on therapy.

Can children take SLIT tablets?

Yes, for specific products and ages (generally 5–65 years for Grastek, Oralair, Ragwitek, and Odactra). An adult must supervise every home dose and keep epinephrine available.

Where is Wyndly’s Colorado clinic for supervised dosing?

255 Union Boulevard, Lakewood, CO 80228. On-site parking is available. For day-of questions, text 720-730-9988 or email care@wyndly.com.

Schedule Your Supervised First SLIT Tablet Dose

For FDA‑approved allergy tablets only (Grastek, Oralair, Ragwitek, Odactra):

Ages 5–65 per U.S. labeling; your clinician will confirm eligibility
First dose must be observed in‑clinic with at least 30 minutes of monitoring
Epinephrine auto‑injector prescription and training are required before home dosing

Book your supervised first dose →

30‑minute observation checklist (bring this to your visit)

Current medication list, including inhalers and any beta‑blockers
Stable asthma and no acute illness today (tell us if symptoms have changed)
Clean, dry hands for tablet placement; do not swallow for 1 minute; no food/drink for 5 minutes after
Plan to remain onsite ≥30 minutes post‑dose; staff and emergency medicines available
Receive epinephrine prescription plus hands‑on trainer practice; leave with written instructions
Children: an adult accompanies the clinic visit and supervises every home dose thereafter

Not near our Colorado clinic?

We coordinate supervised first‑dose visits at approved partner clinics in all 50 states. We’ll secure a local site, confirm ≥30 minutes of observation, and ensure epinephrine training before you begin home dosing.

Fastest coordination: text 720‑730‑9988 or email care@wyndly.com with your city and ZIP
Or book online: Schedule your supervised first dose →

FDA-approved SLIT tablets for grass, ragweed, and dust mite require a supervised first dose with at least 30 minutes of observation and an epinephrine auto-injector for home use.

Current U.S. labels approve use for ages 5–65; confirm product-specific guidance with your clinician.> Inline notice — FDA-approved tablets at a glance: Ages 5–65 per U.S. labels; first dose must be observed in-clinic (≥30 minutes); epinephrine prescription and training required before home dosing.

Boxed‑warning essentials for FDA‑approved SLIT tablets (Grastek, Oralair, Ragwitek, Odactra)

Risk of severe allergic reactions, including anaphylaxis. First dose must be given under medical supervision with at least 30 minutes of observation.

Prescribe an epinephrine auto‑injector and train patients/caregivers to use it before home dosing begins.

Do not use in patients with severe, unstable, or uncontrolled asthma, or with a history of severe systemic allergic reactions to SLIT.

Contraindicated in patients with a history of eosinophilic esophagitis (EoE). Stop treatment and seek care if persistent or severe throat/mouth symptoms occur.

Instruct patients to discontinue dosing and contact a clinician if they experience systemic or severe local reactions.

First dose: what to expect> Sticky CTA — Schedule your supervised first tablet dose

First dose is given under medical supervision with ≥30 minutes of observation. Epinephrine prescription and hands‑on training included.

Schedule your supervised first dose →

Pediatric and caregiver guidance (ages 5–65)

FDA‑approved tablet labels generally cover ages 5–65; your Wyndly clinician will confirm product‑specific eligibility.
An adult must attend the in‑clinic first dose for children and supervise every home dose thereafter.
Caregivers receive epinephrine training at the first‑dose visit; keep auto‑injectors immediately available during therapy.
Ask your care team for school/camp action plans and documentation as needed.

Quick FAQ: Supervised starts and locations

How do I take my first dose if I’m not near Colorado?
Wyndly coordinates your supervised first dose with approved partner clinics in all 50 states. We’ll arrange a local site, confirm observation, and ensure you receive epinephrine training before home dosing.
Do Wyndly drops require a supervised first dose?
No. Custom SLIT drops are started at home; tablets (Grastek, Oralair, Ragwitek, Odactra) require the first dose in clinic.

Printable one‑pager: SLIT tablet safety checklist (for patients and caregivers)

Use this concise, label‑aligned checklist when starting FDA‑approved SLIT tablets (Grastek, Oralair, Ragwitek, Odactra). Print and bring to your supervised first dose.

First dose: Must be given under medical supervision with at least 30 minutes of observation (anaphylaxis risk exists per product boxed warnings)
Epinephrine: You must be prescribed an epinephrine auto‑injector and be trained to use it before any home dosing
Ages: Approved for 5–65 years (see product table below for specifics)
Contraindications: Do not use if you have eosinophilic esophagitis (EoE) or severe/unstable/uncontrolled asthma; do not start during pregnancy; use caution with beta‑blockers
Stop and call your doctor: Systemic reactions (e.g., trouble breathing, throat tightness, dizziness), severe local reactions, or persistent/worsening mouth/throat symptoms
Dosing tips: Dry hands; place tablet under tongue; avoid swallowing for 1 minute; no food/drink for 5 minutes after dosing
Pediatric use: An adult must supervise every dose at home and keep epinephrine immediately available

Where to take your supervised first dose

Colorado: Wyndly Clinic (255 Union Blvd, Lakewood, CO 80228)
Not near Colorado? We’ll coordinate with an approved local partner so you can take your first dose safely under observation

Important: Wyndly treats environmental allergies only. We do not treat food allergies. If pregnant or you develop new/worsening asthma or illness, contact your doctor before dosing. Where this appears on site

This standardized safety card is auto-injected on pet/cat/dog intent pages to clarify first-dose supervision and epinephrine policies for FDA-approved tablets vs. custom SLIT drops.- Pricing and plan pages: Display this safety card alongside treatment pricing/membership details (e.g., quarterly/annual treatment subscriptions) to clarify tablet first-dose rules.
FAQs: Include this card on patient FAQ pages and any question that compares tablets vs. drops or asks about epinephrine requirements.
Tablet timing/seasonality content: Surface this card on pages that explain when to start grass, ragweed, or dust mite tablets (e.g., Grastek/Oralair/Ragwitek/Odactra timing tables) so first-dose supervision is not missed.
Tablet-specific content: Auto-inject on any page that references Grastek, Oralair, Ragwitek, or Odactra by name.
Consult and scheduling: Add a sticky “Schedule supervised first dose” CTA on consult/scheduling pages that links to https://www.wyndly.com/pages/consult and states: “First tablet dose is given under medical supervision with ≥30 minutes of observation; epinephrine training included.”

Sticky CTA (spec)

Label: Schedule your supervised tablet start
Link: https://www.wyndly.com/pages/consult
Notes: Persistent footer on consult/scheduling pages; reiterate in-clinic first dose, ≥30 minutes observation, and epinephrine prescription/training.

Quick safety card — Tablets vs. Drops

FDA-approved SLIT tablets (Grastek, Oralair, Ragwitek, Odactra)
First dose: Must be given under medical supervision with ≥30 minutes of observation
Epinephrine: Must be prescribed; patient/caregiver trained before home dosing
Ages: Generally 5–65 years (see product labeling above)
Key cautions: Do not use with EoE or severe/unstable/uncontrolled asthma; pause if significant mouth/throat symptoms develop; do not initiate during pregnancy
Custom SLIT drops (oral allergy drops)
First dose: Taken at home; routine in-clinic first dose is not required
Epinephrine: Not routinely required for all patients; may be prescribed at clinician discretion
Ages: Typically 5+ with clinician guidance
Key cautions: Stop dosing and contact your clinician for systemic or severe local reactions; not for food allergies

At-a-glance (first dose and epinephrine)

Tablets: Supervised first dose in clinic; carry epinephrine while on therapy
Drops: No supervised first dose required; epinephrine based on clinician judgment

Book your supervised first dose → https://www.wyndly.com/pages/consult Schedule your supervised first tablet start

Book now → Prefer to speak first? Meet with a doctor →
Not near our Colorado clinic? We’ll coordinate with a local partner so you can take your first dose safely under observation.

Why first‑dose supervision matters

FDA‑approved sublingual immunotherapy (SLIT) tablets for environmental allergies require an in‑clinic first dose with observation. This visit confirms you tolerate the medicine, teaches safe self‑administration at home, and ensures you are trained to use epinephrine.

Which tablets this applies to (as of October 18, 2025)

Tablet (brand)	Allergen	FDA‑approved ages	When to start
Grastek (Timothy grass)	Grass pollen	5–65 years	Begin ≥12 weeks before grass season and take daily in season
Oralair (5‑grass mix)	Grass pollen	5–65 years	Begin ~4 months before grass season and take daily in season
Ragwitek (short ragweed)	Ragweed pollen	5–65 years	Begin ≥12 weeks before ragweed season and take daily in season
Odactra (house dust mite)	Dust mites	5–65 years	Daily, year‑round

Notes> Sticky CTA — Schedule your supervised tablet start

First dose given in clinic with ≥30 minutes of observation

Applies to FDA‑approved tablets: Grastek, Oralair, Ragwitek, Odactra (ages 5–65)

Epinephrine prescription and hands‑on training included

24/7 doctor access before and after your visit

Schedule your supervised tablet start →

First dose for each tablet must be supervised in a healthcare setting with at least 30 minutes of observation.
An epinephrine auto‑injector must be prescribed and you (or your caregiver) must be trained to use it.

Before your appointment

Medical review and screening
Tell your doctor about asthma control, prior severe reactions to allergy tablets/drops, history of eosinophilic esophagitis (EoE), oral ulcers/surgery, and all medications (especially beta‑blockers).
We do not initiate SLIT during pregnancy. If you become pregnant while on therapy, contact your doctor.
Logistics
Bring your medication list and any inhalers you use for asthma.
Avoid eating or drinking for 15 minutes before the visit if possible.

Day‑of‑visit checklist (first tablet dose)We coordinate your supervised first dose in your state when possible. Plan for at least 30 minutes of post‑dose observation; hands‑on epinephrine training is included at this visit.

What to bring (and do) for your first tablet dose

Government‑issued photo ID and a guardian for minors (an adult must attend and supervise future home doses)
Current medication list, including inhalers, asthma meds, and any beta‑blockers
Your allergy history and any recent illnesses or mouth/dental procedures (tell us if you’ve had new/worsening asthma, oral ulcers, or surgery)
A charged phone so you can text the care team if needed
Avoid food and drink for 15 minutes before arrival; after dosing, no food or drink for 5 minutes
Wear something comfortable and plan to remain in the clinic for ≥30 minutes after dosing
Confirm you’ll leave with an epinephrine auto‑injector and written instructions after training

Traveling or not near Colorado? Book a consult and we’ll coordinate your supervised first dose with an approved local partner so you can start safely under observation.

Where can I take my supervised first dose?

Book your supervised first dose at our Colorado clinic or with an approved partner clinic.
First dose includes ≥30 minutes of observation and hands‑on epinephrine training.

Book now

Schedule your supervised tablet start →
Prefer a general consult first? Meet with a doctor →

Partner‑clinic locator

Find a supervised first dose near you (mini‑locator)

Fastest option: Text 720-730-9988 or email care@wyndly.com with your city and ZIP. We’ll coordinate an approved local clinic, confirm ≥30 minutes of observation, and arrange epinephrine training before home dosing.
Prefer to book online? Schedule a consult →

Pick your state (we serve all 50 states)

Printable first‑dose checklist (PDF‑friendly)

Tip: Use your browser’s Print function for a clean handout (File → Print or Ctrl/Cmd+P).

Applies to: FDA‑approved SLIT tablets — Grastek, Oralair, Ragwitek, Odactra (generally ages 5–65; your clinician will confirm)
First dose: Take in a healthcare setting with ≥30 minutes of observation
Epinephrine: Prescription and hands‑on training required before any home dosing
Do not start if: Severe/unstable/uncontrolled asthma, or history of eosinophilic esophagitis (EoE)
Pause and call if: Significant mouth/throat symptoms, systemic symptoms, or new respiratory illness
Pediatric notes: An adult must attend the clinic visit and supervise every home dose thereafter
Day‑of tips: Dry hands; place tablet under tongue; don’t swallow for 1 minute; avoid food/drink for 5 minutes after; bring current medication list (include inhalers/beta‑blockers)
Contact: care@wyndly.com • Text 720‑730‑9988 • Schedule a consult

Colorado — Wyndly Clinic (Lakewood): 255 Union Boulevard, Lakewood, CO 80228
ADVENT offices — Start in‑clinic with ADVENT; ongoing care through Wyndly:
Program & pricing: ADVENT payment
Clinical overview: Wyndly × ADVENT
Not near Colorado or an ADVENT office? Book a consult and we’ll help coordinate your supervised first dose locally.

Quick FAQs

Do children need supervised first doses? Yes. FDA‑approved tablets (Grastek, Oralair, Ragwitek, Odactra) require an in‑clinic first dose for ages 5–65. An adult must supervise every home dose thereafter.
Do I need epinephrine? Yes. You’ll be prescribed an epinephrine auto‑injector and trained to use it at your first‑dose visit. Keep it accessible while on therapy.
Bring a current medication list (include inhalers and any beta‑blockers)
Have your asthma well controlled; reschedule if you’re sick
Do not eat or drink for 15 minutes before or 5 minutes after dosing
Plan for at least 30 minutes of post‑dose observation
Confirm you have an epinephrine auto‑injector at home after training

Where to go in Colorado (Wyndly clinic)

Address: 255 Union Boulevard, Lakewood, CO 80228
Parking: On‑site surface and garage parking available
What to expect: Check‑in, safety review, supervised first dose, ≥30‑minute observation, epinephrine training
Questions day‑of? Text 720‑730‑9988 or email care@wyndly.com

Prefer to pick a time now?

Book your supervised first dose →

Partner clinics: ADVENT patients

If you’re starting therapy through an ADVENT office, you’ll take your first dose in‑clinic with ADVENT. Wyndly is ADVENT’s trusted partner for ongoing drops and support.

Program details and pricing: ADVENT payment page
Clinical overview for ADVENT patients and teams: Wyndly × ADVENT

What happens at your first supervised dose (30–45 minutes total)

1) Check‑in and safety review (5–10 min)

Confirm eligibility (stable asthma, no acute illness). Review how tablets work and when to call us.

2) Hands‑on administration (5 min)

With clean, dry hands, place the tablet under your tongue; do not swallow for at least 1 minute. Do not eat or drink for 5 minutes after placement.

3) Observation period (≥30 min)

You remain in the clinic where staff and emergency medicines (including epinephrine) are immediately available.
We monitor for throat/mouth itching, swelling, hives, trouble breathing, dizziness, or stomach symptoms.

4) Epinephrine training and discharge (5–10 min)

Practice with a trainer device. You’ll leave with an active auto‑injector and written instructions.
Children: an adult must supervise every home dose and keep epinephrine reachable at all times.

After your visit: daily home dosing

Take one tablet daily as directed. Seasonal tablets (Grastek, Oralair, Ragwitek) begin before and continue through the season; Odactra is year‑round.
If you miss doses, develop mouth/throat sores, have dental procedures, or notice escalating throat symptoms, pause and contact your doctor before restarting.
Keep epinephrine with you while on therapy. If you ever need to use it, call 911 and notify your care team.

When to delay or stop a dose and call your doctor

New or worsening asthma symptoms or respiratory infection
Persistent or worsening mouth/throat swelling or pain
Oral surgery, active mouth ulcers, or significant dental work
Any severe reaction symptoms (breathing difficulty, throat tightness, fainting, severe GI symptoms)

Pediatric guidance (ages 5+)

Age approvals vary by tablet (see table). An adult must:
Supervise each dose and the post‑dose period.
Maintain immediate access to the child’s epinephrine auto‑injector and know how to use it.

How Wyndly supports you

Doctor‑led care and 24/7 support are included with your plan. Start with a consult, then your doctor will decide if an FDA‑approved tablet (or custom drops) is the right fit: Allergy consult • Immunotherapy overview • Patient FAQs

Quick answers

How long am I observed? At least 30 minutes after the first dose.
Do I need epinephrine? Yes—everyone on SLIT tablets must have epinephrine and training.
Can I take my first dose at home? No. Only doses after the first supervised dose are taken at home.
Can kids use tablets? Yes, for specific tablets/ages shown above; adult supervision is required.

References (labeling and safety standards)

Grastek (Timothy grass) US Prescribing Information (boxed warning; first‑dose supervision; ages 5–65; epinephrine training).
Ragwitek (short ragweed) US Prescribing Information (first‑dose supervision; ages 5–65; epinephrine training).
Oralair (5‑grass) US Prescribing Information (first‑dose supervision; ages 5–65).
Odactra (house dust mite) US Prescribing Information and FDA approval updates (first‑dose supervision; ages 5–65; 2025 pediatric expansion).

First‑dose supervision for FDA‑approved allergy tablets (SLIT): what to expect