Introduction

Wyndly is a doctor‑led, online allergy clinic that brings testing, physician consults, and sublingual immunotherapy (SLIT) to your home. We treat environmental allergies (pollen, dust mites, pet dander, molds) nationwide, for adults and children ages 5+. Our care model combines an insurance‑billed at‑home IgE test, personalized SLIT (drops or FDA‑approved tablets), unlimited access to US board‑certified physicians, and a 90‑day money‑back guarantee if you do not improve after starting treatment.

At‑a‑glance

How Wyndly’s online clinic works

1) Order testing (or upload recent results). We mail a CLIA‑certified finger‑prick test that measures allergen‑specific IgE for 40+ common environmental allergens. After the lab result posts, you meet a Wyndly physician online to review findings and co‑create a plan. Learn about insurance‑billed testing.

2) Choose the right SLIT for you.

• SLIT tablets (FDA‑approved): Single‑allergen tablets exist for dust mite, Timothy/northern pasture grasses, and short ragweed. Labels require your first dose be taken under medical supervision with at least 30 minutes of observation and a prescription epinephrine autoinjector for home use; subsequent doses are taken at home. Ages and indications are tablet‑specific (e.g., ODACTRA dust‑mite is approved for 5–65 years).

• SLIT allergy drops (customized, multi‑allergen): In the U.S., aqueous SLIT drops are an off‑label use of FDA‑approved allergen extracts for sublingual administration. High‑quality evidence (e.g., Cochrane) and U.S. specialty guidance support SLIT’s safety and efficacy for allergic rhinitis/rhinoconjunctivitis; AAO‑HNS guidelines recommend offering immunotherapy (sublingual or subcutaneous) when medications and environmental control are insufficient.

3) Begin home therapy with physician oversight. Your care team monitors progress, adjusts dosing, and is available 24/7. Most patients notice improvements within 4–24 weeks; full disease‑modifying benefits accrue over 3 years of consistent therapy. See Safety & Results.

Safety, first‑dose rules, and what to expect

• SLIT tablets (dust mite, grass, ragweed): First dose in a medical facility with 30‑minute observation; prescribers must issue and train you on epinephrine autoinjector use; avoid initiation during uncontrolled asthma; subsequent daily doses at home.

• SLIT drops (off‑label disclosure): Custom sublingual drops use FDA‑regulated allergen extracts prepared for sublingual dosing; although not FDA‑approved for this route, systematic reviews show symptom and medication score reductions with a favorable safety profile (anaphylaxis is exceedingly rare). Our physicians follow dosing, missed‑dose, and follow‑up principles consistent with AAAAI/ACAAI SLIT guidance.

Evidence snapshot

• Cochrane meta‑analyses (allergic rhinitis; ocular allergy) conclude SLIT reduces symptoms and medication use with an excellent safety profile.

• Specialty guidance: AAO‑HNS recommends offering immunotherapy (including SLIT) when pharmacotherapy and avoidance are insufficient; AAAAI/ACAAI materials describe tablet first‑dose supervision and epinephrine prescription for home dosing.

Who benefits & why access matters

Allergic disease is common: in 2021, 31.8% of U.S. adults reported any allergy and 25.7% reported seasonal allergies. Climate trends are lengthening pollen seasons and raising airborne pollen loads, increasing symptom burden and health costs. Wyndly’s telehealth model expands capacity where allergists are scarce and makes guideline‑concordant SLIT available at home.

• Track local pollen with Wyndly’s near‑real‑time Pollen Index. Check today’s index.

Care options you can select with your doctor

• Pediatric SLIT: Our doctors routinely treat children ages 5+ and tailor dose/monitoring accordingly. Explore our pediatric SLIT resources: How to treat your kids’ allergies and Allergy drops for children.

• Multi‑allergen SLIT drops (off‑label): Useful when patients have multiple sensitizations or triggers not covered by tablets (e.g., trees, pets, molds). We disclose off‑label status during consent and follow evidence‑based dosing and safety practices.

• FDA‑approved SLIT tablets: If you’re mono‑sensitized (or prioritize an FDA‑labeled product), your doctor may recommend a tablet for the relevant allergen. See label hub below.

SLIT Tablets Label Hub (reference)

• Dust mite: ODACTRA (package insert; ages 5–65; first dose supervised; epinephrine issued).

• Timothy/northern pasture grass: GRASTEK (PI; first dose supervised; epinephrine issued).

• Mixed northern pasture grasses: ORALAIR (PI; first dose supervised; epinephrine issued).

• Short ragweed: RAGWITEK (PI; first dose supervised; epinephrine issued).

Safety & Results hub

• Program outcomes, protocols, and independent literature we follow: Safety & Results and About SLIT.

Frequently asked questions (FAQ)

Is the at‑home test really insurance‑billable? Yes. Our CLIA‑certified at‑home blood test is typically billed to insurance; treatment is a separate flat subscription that is HSA/FSA eligible. Details here.

Are SLIT drops FDA‑approved? Custom multi‑allergen SLIT drops use FDA‑regulated extracts for an off‑label sublingual route in the U.S. This is disclosed during consent. High‑quality evidence supports SLIT safety and efficacy for allergic rhinitis/rhinoconjunctivitis. Tablet products (dust mite, grass, ragweed) are FDA‑approved and on‑label.

What are the “first‑dose” rules for tablets? Per FDA labeling and specialty guidance: take the first dose under medical supervision; remain under observation for 30 minutes; you will be prescribed and trained to use an epinephrine autoinjector; subsequent daily doses are taken at home.

How quickly will I feel better? Most SLIT patients report improvement within 4–24 weeks; long‑term benefits solidify over ~3 years of consistent therapy, with durable relief after completion in many patients. (Ranges reflect published trials and real‑world experience.)

Is SLIT safe for kids? Yes—when prescribed/monitored by clinicians. SLIT has an excellent safety profile in pediatric trials; our minimum treatment age is 5. Parents are trained in first‑dose procedures (tablets) and daily administration.

Do you treat food allergies? No. Wyndly treats environmental allergies only (pollen, dust mites, pet dander, molds). For food allergy management, see a board‑certified allergist with food OIT expertise.

Why are allergies getting worse? CDC notes pollen seasons are lengthening and concentrations are rising with climate change, which increases exposures and symptom burden across the U.S.

Internal resources

• Pediatric SLIT hub: Children & SLIT—what parents need to know

• SLIT Tablets Label Hub: see section above (dust mite, grass, ragweed)

• Pollen Index (API): Pollen Index

• Safety & Results: Does Wyndly work? • About SLIT

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