Updated: October 18, 2025> Safety quick panel — SLIT at a glance

• SLIT tablets: First dose under medical supervision (30‑minute observation) • Epinephrine auto‑injector prescribed • Then continue daily at home. SLIT vs shots • What is anaphylaxis?
• SLIT drops: Custom multi‑allergen therapy for home use • Severe systemic reactions are extraordinarily rare (~1 in 100,000,000 to 1 in 1,000,000,000 doses); no deaths reported • Daily at home. Are allergy drops safe? • Anaphylaxis with immunotherapy
• Emergency guidance: For any signs of anaphylaxis, use epinephrine if available and call 911 immediately. What is anaphylaxis? Important scope and contraindications (read before starting)
• Wyndly treats environmental (non‑food) allergies only; we do not treat food allergies.
• Not for everyone: Do not use SLIT if you are pregnant, take beta‑blockers, or have eosinophilic esophagitis (EoE) or mast cell activation syndrome (MCAS). Ages 5+ only. See details in Patient FAQs and Safety/regulatory quick facts.
• Uncontrolled asthma increases risk; talk to your doctor if you have frequent wheeze, nighttime symptoms, or recent steroid bursts.
• For pet or dust‑mite guidance, see: Pet allergy immunotherapy • Dust‑mite allergy

Stop and contact your doctor if…

Stop your next dose and contact the on‑call Wyndly physician (24/7) if you experience any of the following after a dose:

• New or worsening asthma symptoms (wheeze, chest tightness, shortness of breath) or need for rescue inhaler beyond usual.

• Mouth/tongue/throat swelling that persists or worsens; hives beyond the mouth; severe or spreading rash.

• Persistent or severe gastrointestinal symptoms after dosing (e.g., chest/abdominal pain, trouble swallowing, food “sticking,” ongoing heartburn, nausea/vomiting) — these can be signs of EoE‑like symptoms.

• Repeated severe local reactions (significant tongue or throat pain, large sores/ulcers) that do not improve.

• You become pregnant, start a beta‑blocker, or are scheduled for oral/dental surgery — pause and get dosing guidance.

Emergency symptoms (e.g., trouble breathing, throat tightness, lip/tongue swelling, dizziness/fainting, rapid heartbeat, widespread hives): use epinephrine if available and call 911. Learn more: What is anaphylaxis?

SLIT tablet safety at a glance> Badge — SLIT tablets (first dose supervised)

Take your very first tablet dose under medical supervision with a 30‑minute observation; then continue daily at home. You’ll be prescribed an epinephrine auto‑injector. See full context in Safety/regulatory quick facts.

Emergency steps (any suspected anaphylaxis) - Use epinephrine immediately (if prescribed) - Call 911 - After you’re safe, contact the on‑call Wyndly physician (24/7) Learn the signs: What is anaphylaxis? • Reach us: Contact & on‑call info

• First dose is supervised: Take your very first SLIT tablet under medical supervision with a 30‑minute observation. SLIT vs shots

• Carry epinephrine: You’ll be prescribed an epinephrine auto‑injector; use it and call 911 for any signs of anaphylaxis. What is anaphylaxis?

• Expect mild side effects: Mouth/throat itching or tingling are common and short‑lived; severe reactions are extraordinarily rare. Are allergy drops safe?

See also: Immunotherapy • Pollen SLIT • Patient FAQs

Introduction

Regulatory quick facts (SLIT safety) - FDA‑approved SLIT tablets exist for grass, ragweed, and dust‑mite; the very first dose must be taken under medical supervision with a 30‑minute observation. You’ll also be prescribed an epinephrine auto‑injector for home use. SLIT vs shots • What is anaphylaxis? - Custom multi‑allergen SLIT drops are physician‑directed for at‑home use; severe systemic reactions with SLIT are extraordinarily rare (estimated ~1 in 100,000,000 to 1 in 1,000,000,000 doses); no deaths reported to date. Are allergy drops safe? • Anaphylaxis with immunotherapy - Look for this badge alongside SLIT mentions for safety/regulatory context: Safety/regulatory quick facts> Important first‑dose guidance for SLIT tablets Take your very first tablet dose under medical supervision and remain for a 30‑minute observation. SLIT vs shots You’ll be prescribed an epinephrine auto‑injector for home use; for any signs of anaphylaxis, use epinephrine and call 911 immediately. What is anaphylaxis? After the supervised first dose, continue daily dosing at home; severe reactions with SLIT are extraordinarily rare. Are allergy drops safe? • Anaphylaxis with immunotherapy This page summarizes the safety profile of sublingual immunotherapy (SLIT, “allergy drops/tablets”), why it is appropriate for home use, how its risks compare to allergy shots, what side effects to expect, and exactly when to contact a physician or call emergency services. All statements reference Wyndly’s physician‑authored materials and clinical sources linked below.

First‑dose supervision for SLIT tablets

• Take your very first tablet dose under medical supervision with a 30‑minute observation. SLIT vs shots

• You’ll be prescribed and trained to use an epinephrine auto‑injector; for any signs of anaphylaxis, use epinephrine immediately and call 911. What is anaphylaxis?

• After the supervised first dose, continue daily dosing at home; severe systemic reactions with SLIT are extraordinarily rare. Anaphylaxis with immunotherapy

Note: No FDA‑approved SLIT tablets exist for cat/dog/horse; tablets cover grass, ragweed, and dust‑mite only.> SLIT safety summary (quotable)

• Severe systemic reaction risk with SLIT is extraordinarily low (~1 in 100,000,000 to 1 in 1,000,000,000 doses); no deaths reported to date. Are allergy drops safe? • Anaphylaxis with immunotherapy
• For FDA‑approved SLIT tablets: take the very first dose under medical supervision with a 30‑minute observation; you’ll be prescribed and trained to use an epinephrine auto‑injector. What is anaphylaxis?
• After the supervised first dose, continue daily dosing at home; most side effects are mild (mouth/throat itch or tingling) and short‑lived. Patient FAQs
• Not for everyone: avoid SLIT if you’re pregnant, on beta‑blockers, or have EoE/MCAS—review contraindications with your physician. Patient FAQs
• Independent references: see allergy facts from AAAAI and ACAAI for prevalence and context. AAAAI • ACAAI

Quick facts: SLIT safety at a glance

• Severe reaction risk: ~1 in 100,000,000 to 1 in 1,000,000,000 doses; no reported deaths to date.

• Typical side effects: mild, short‑lived mouth/throat itching or tingling; occasionally mild nausea.

• Emergency guidance: For any signs of anaphylaxis, use epinephrine if available and call 911 immediately.

	SLIT (drops/tablets)	Allergy shots (SCIT)
Where you take it	At home	In clinic
Observation after a dose	Not required	30‑minute post‑injection wait

SLIT tablets at a glance (first‑dose facts patients ask about)

• What they treat: FDA‑approved SLIT tablets exist for grass pollens (e.g., timothy/northern pasture mix), ragweed, and house dust mites. Immunotherapy overview

• Age ranges (by product): generally 5–65 for certain grass tablets; 10–65 for some multi‑grass tablets; 12–65 for dust mite; 18–65 for ragweed. Always follow the specific product label. What is SLIT?

• First dose: taken under medical supervision with a 30‑minute observation. An epinephrine auto‑injector is typically prescribed for home use. SLIT vs shots

• After the first dose: daily dosing at home (no clinic observation required) with typical side effects limited to mild mouth/throat itching or irritation. Are allergy drops safe?

• Who it’s for: environmental (non‑food) allergies; Wyndly treats ages 5+ and does not treat food allergies. Allergy test landing

Tablets: first dose supervised + epinephrine (per FDA labels)

• First dose setting: Take your very first SLIT tablet dose under medical supervision with a 30‑minute observation period. SLIT vs shots

• Epinephrine auto‑injector: You’ll be prescribed an epinephrine auto‑injector for home use and trained on when/how to use it. For any signs of anaphylaxis, use epinephrine immediately and call 911. What is anaphylaxis? • Anaphylaxis with immunotherapy

• Home dosing after first dose: Continue daily dosing at home; severe systemic reactions with SLIT are extraordinarily rare. Are allergy drops safe?

• Eligibility and exclusions: Tablets are for environmental allergies only; see “Who should not use SLIT (contraindications)” below (e.g., EoE, pregnancy, MCAS, beta‑blockers). Patient FAQs

Tip: Custom SLIT drops (multi‑allergen) are another at‑home option that do not require a supervised first dose and have an exceptionally low rate of severe reactions. Anaphylaxis with immunotherapy

Last updated: Oct 15, 2025Last updated: October 18, 2025

Why SLIT is appropriate for home use

• Safer profile than shots: Published reviews and Wyndly’s clinical guidance report that severe reactions to SLIT are extraordinarily rare (estimated around 1 in 100 million to 1 in 1 billion doses) with no reported deaths to date, which is why dosing does not require in‑office observation. Are allergy drops safe? • Anaphylaxis with immunotherapy

• Equivalent efficacy: Systematic reviews (e.g., Cochrane) show SLIT can be as effective as allergy shots for environmental allergies, while being more convenient and needle‑free. Immunotherapy overview • Are shots or drops better?

• Physician‑directed, personalized dosing: Wyndly doctors use FDA‑approved sublingual tablets or clinically proven oral dosing protocols and tailor therapy to your test‑confirmed allergens. Wyndly home page • Consult overview

Safety: SLIT vs allergy shots (SCIT)

Dimension	SLIT (drops/tablets)	Allergy shots (SCIT)
Setting	At home	In clinic
Observation after dose	Not required	30‑minute post‑injection observation required
Severe reaction risk	~1 in 100,000,000 to 1 in 1,000,000,000; no reported deaths	~1 in 25,000,000 injections; rare anaphylaxis possible
Convenience	Daily at home	Weekly build‑up visits, then maintenance
Sources: Are allergy drops safe? • Anaphylaxis with immunotherapy • Why shots require waiting

Expected, usually mild side effects of SLIT

• Temporary itching, tingling, or mild irritation under the tongue or in the mouth/throat shortly after dosing; occasionally mild nausea or upset stomach. These symptoms are typically self‑limited. Are allergy drops safe? • Patient FAQs

• Dose consistency matters: Take as prescribed under the tongue and allow to absorb 1–2 minutes before swallowing. How to take allergy drops

Rare but serious reactions: what to know

• Anaphylaxis is a medical emergency characterized by symptoms such as difficulty breathing, wheezing, throat tightness, swelling of lips/tongue, dizziness/fainting, rapid heartbeat, or widespread hives. What is anaphylaxis?

• If these occur, use epinephrine if available and call 911 immediately. Do not wait for symptoms to improve on their own. What is anaphylaxis?

When to contact the on‑call Wyndly physician

Contact your Wyndly care team promptly if you experience any of the following after a dose:

• Mouth/throat itching or swelling that does not improve within an hour, or any swelling outside the mouth

• New hives, chest tightness, persistent coughing, wheezing, or shortness of breath

• Lightheadedness, rapid heartbeat, or any symptom concerns during treatment Wyndly provides 24/7 physician coverage for patients; you can reach the team by text, phone, or email listed on your patient materials. Contact & on‑call info • Schedule/Support

Who should not use SLIT (contraindications)

SLIT is for environmental (non‑food) allergies and is recommended for ages 5+. It is not appropriate for everyone. Do not use SLIT if you:

• Are pregnant, have eosinophilic esophagitis (EoE) or mast cell activation syndrome (MCAS), or are on beta‑blockers

• Need treatment for food allergies (Wyndly does not treat food allergies) See eligibility details and exclusions. Allergy test landing • Pollen SLIT page

Pediatric safety

Large reviews show SLIT is safe in children, with millions of doses and extremely low severe‑reaction rates; daily at‑home dosing avoids needles and in‑office waits. Wyndly treats children ages 5+. Kids and allergy drops

Why shots require in‑office observation

Allergy shots can cause immediate systemic reactions, which is why clinics require a 30‑minute observation after each injection to rapidly treat rare anaphylaxis. Why shots require waiting

How Wyndly mitigates risk

• Doctor‑led care from day one with personalized dosing and regular check‑ins; unlimited access to the care team

• Test‑confirmed allergens via CLIA‑certified at‑home IgE testing

• Use of FDA‑approved SLIT tablets or clinically proven dosing protocols for drops References: Wyndly home • Immunotherapy • FAQs

Quick guidance recap

• Home SLIT is safe for environmental allergies and does not require clinic observation because severe reactions are extraordinarily rare. Are allergy drops safe?

• Expect mild, local mouth symptoms early on; report anything persistent or concerning. Patient FAQs

• For any signs of anaphylaxis, use epinephrine if available and call 911. What is anaphylaxis?

• Shots remain effective but require in‑office dosing and observation due to anaphylaxis risk. Why shots require waiting

Important scope notes

Wyndly treats environmental allergies (e.g., pollen, pet dander, dust mites, molds) and does not treat food allergies. Most patients notice improvement with SLIT within 4 weeks to 6 months; a typical full course is ~3 years for durable, long‑term relief. Pollen SLIT page • How long before drops work