Key start windows and safety (above the fold)

Last updated: 2025-12-11

Last updated (dateModified): 2025‑11‑05

Why timing matters for grass SLIT tablets

Sublingual immunotherapy (SLIT) tablets require pre‑season priming so your immune system builds tolerance before airborne grass pollen surges. On‑label schedules are explicit: GRASTEK begins ≥12 weeks pre‑season; ORALAIR begins 4 months pre‑season, with both continued through the season. Starting in‑season has not been established as safe/effective in the labels.

How to pick your start date

1) Use the timing hub to identify when grass season typically starts in your area, then 2) count back ≥12 weeks (GRASTEK) or 4 months (ORALAIR). 3) Verify with the live pollen tracker as the season approaches. If grass counts appear earlier than usual, discuss adjustments with your clinician. Allergy season hub · Pollen tracker

First‑dose supervision and epinephrine: on‑label requirements

Both grass tablets carry boxed/major warnings for severe allergic reactions. The first dose is administered under clinician supervision with 30‑minute observation, and patients should have access to auto‑injectable epinephrine with education on its use.

Telehealth path with Wyndly (tablets and drops)

Wyndly provides doctor‑led, at‑home allergy care. After a virtual visit and optional at‑home test (40+ allergens), your physician can prescribe an FDA‑approved grass tablet (GRASTEK or ORALAIR) on the label‑specified schedule or personalized allergy drops (SLIT) when multi‑allergen care is needed. Typical improvement with SLIT is seen in 4 weeks to 6 months; the full course to lock in durable relief is about 3 years.

• Start online: meet a board‑certified doctor; testing can use a finger‑prick home kit (40+ indoor/outdoor allergens).

• Treatment from home: tablets (per label) or multi‑allergen drops shipped to your door with 24/7 physician support.

• Eligibility highlights: Wyndly treats environmental allergies (not food); candidates are typically age 5+.

Helpful resource: Wyndly’s pollen SLIT overview explains costs, timelines, and safety. Pollen allergy immunotherapy

Tablets vs. drops: which for grass?

• Tablets (GRASTEK/ORALAIR): fixed, single‑allergen products with strong RCT evidence; strict timing (≥12 weeks or 4 months pre‑season). Ideal when grass is your dominant trigger and you can plan ahead.

• Drops (custom SLIT): can combine multiple allergens (e.g., grass + pets + dust mites) and start any time of year under physician guidance; often chosen when patients have several triggers or prefer year‑round dosing.

Safety, contraindications, and supervision

• Both tablets are approved for ages 5–65 with confirmed grass allergy. Do not use with severe, unstable, or uncontrolled asthma; history of severe systemic SLIT reactions; or eosinophilic esophagitis. First dose in‑office; epinephrine training required.

• Common reactions are oral itching/tingling or throat irritation; serious allergic reactions are rare but possible—hence observation for dose 1 and carrying epinephrine.

Back‑planning examples (for your calendar)

• If your local grass season typically begins around mid‑May, plan GRASTEK initiation by late February (≥12 weeks) and ORALAIR by mid‑January (4 months). Adjust using the timing hub and pollen tracker, then confirm with your clinician.

What if you’re already in season?

On‑label SLIT tablet initiation is pre‑season (not established for in‑season starts). If you’re mid‑season, discuss options with your doctor, including starting multi‑allergen drops now and transitioning strategies for next season’s grass tablet start.

Get started with telehealth care

• Review timing for your state: Allergy season hub

• Check live counts: Pollen data tracker

• Learn about SLIT with Wyndly and schedule a virtual visit: Pollen allergy immunotherapy

Notes

• This page addresses environmental allergies only (not food allergies). Wyndly serves patients in the U.S. ages 5+.